- Bills vs. Texans50¢
- Spread: Bills (-2.5)46¢
- Bills vs. Texans: O/U 41.561¢
- Bills vs. Texans: O/U 47.540¢
- Spread: Bills (-4.5)33¢
- Bills vs. Texans: O/U 46.544¢
- Spread: Bills (-3.5)38¢
- Bills vs. Texans: O/U 43.554¢
- Spread: Bills (-1.5)47¢
- Bills vs. Texans: O/U 44.549¢
- Bills vs. Texans: O/U 54.525¢
- Bills vs. Texans: O/U 64.510¢
In the upcoming NFL game, scheduled for September 13 at 1:00PM ET: If Bills wins, the market will resolve to "Bills". If Texans wins, the market will resolve to "Texans". If the game is postponed, this market will remain open until the game has been completed. If the game is canceled entirely or ends in a tie, with no make-up game, this market will resolve 50-50.
The Buffalo Bills open the 2026 NFL season on the road against the Houston Texans at NRG Stadium, a venue where Buffalo has lost its last six visits. Josh Allen and the offense face a Texans defense that has consistently pressured quarterbacks and limited rushing production in recent seasons, while Houston’s improved offensive line and added backfield depth aim to support C.J. Stroud. Injury reports remain fluid heading into Week 1, with Buffalo monitoring wide receivers Khalil Shakir and Keon Coleman plus running back Ty Johnson, alongside tight end Dalton Kincaid’s confirmed absence. The Texans are tracking right tackle Braden Smith’s foot issue and several other questionable designations. Roster additions such as D.J. Moore for the Bills and overall line upgrades for Houston shape early-season expectations around passing volume, run-game efficiency, and turnover battle in the dome.