- Southeast Missouri State vs. Iowa State3¢
- Spread: Iowa State (-29.5)52¢
- O/U 53.551¢
- Southeast Missouri State Team Total: O/U 11.548¢
- Southeast Missouri State Team Total: O/U 14.528¢
- Southeast Missouri State Team Total: O/U 5.581¢
- Southeast Missouri State Team Total: O/U 8.562¢
- Spread: Iowa State (-0.5)50¢
- Spread: Iowa State (-14.5)86¢
- Spread: Iowa State (-16.5)83¢
- Spread: Iowa State (-17.5)81¢
- Spread: Iowa State (-20.5)75¢
In the upcoming college football game, scheduled for September 5 at 1:00PM ET: If Southeast Missouri State wins, the market will resolve to "Southeast Missouri State". If Iowa State wins, the market will resolve to "Iowa State". If the game is postponed, this market will remain open until the game has been completed. If the game is canceled entirely or ends in a tie, with no make-up game, this market will resolve 50-50.
Iowa State enters its 2026 season opener as a heavy favorite against FCS Southeast Missouri State, with traders pricing the Cyclones at roughly 96-98% implied win probability due to the massive FBS-FCS gap and home-field advantage at Jack Trice Stadium. New head coach Jimmy Rogers oversees a roster with zero returning starters and roughly 80 newcomers, including transfers, creating uncertainty around scheme implementation and cohesion in the first game. Southeast Missouri State arrives with early momentum after a 23-21 Week 0 win over Indiana State, led by quarterback Braylen Ragland’s passing attack, yet faces steep challenges in talent, depth, and physicality against a Big 12 defense. Minor injury questions on Iowa State’s side, such as wide receiver J. Bailey being out, are unlikely to shift the outcome materially.