More markets for the La Liga game, scheduled for September 4 at 3:00 PM ET.
Real Madrid enter the early-season La Liga clash against Real Betis as clear favorites, buoyed by their deeper squad and attacking options including Vinícius Júnior and Kylian Mbappé despite several defensive injuries to players like Éder Militão, Ferland Mendy, and Raúl Asencio. The September 4 fixture at La Cartuja marks Real Madrid's fourth match under Mourinho and the third of three consecutive away games, while Betis face multiple absences including key attackers like Giovani Lo Celso and Abde Ezzalzouli. Recent head-to-head results show a competitive edge for Madrid, including a 5-1 win in January 2026 and a 1-1 draw in April, though the new campaign's limited fixtures leave little form data to separate the sides beyond historical patterns and roster strength.