- Tulane vs. Duke26¢
- Spread: Duke (-9.5)48¢
- O/U 51.548¢
- Tulane vs. Duke: O/U 50.551¢
- Spread: Duke (-7.5)52¢
- Spread: Duke (-8.5)49¢
- 2H Spread: Duke (-7.5)33¢
- Spread: Duke (-10.5)43¢
- Spread: Duke (-20.5)22¢
- Spread: Duke (-27.5)11¢
- Tulane vs. Duke: O/U 45.563¢
- Tulane vs. Duke: O/U 57.535¢
In the upcoming college football game, scheduled for September 5 at 3:30PM ET: If Tulane wins, the market will resolve to "Tulane". If Duke wins, the market will resolve to "Duke". If the game is postponed, this market will remain open until the game has been completed. If the game is canceled entirely or ends in a tie, with no make-up game, this market will resolve 50-50.
Duke enters the 2026 season opener as the home favorite against Tulane, buoyed by its status as defending ACC champion and a returning 1,000-yard rusher in Nate Sheppard. The Blue Devils face notable turnover at quarterback with Walker Eget stepping in for Darian Mensah, who transferred to Miami, while offensive coordinator Jonathan Brewer looks to build on prior offensive production. Tulane, the reigning AAC champion, opens a new era under head coach Will Hall and offensive coordinator Russ Callaway following the departures of prior leadership and key contributors, including its starting quarterback. Both sides deal with injuries—Duke loses offensive lineman Roman Fina for the season, while Tulane’s Jamauri McClure is sidelined with a foot issue. The matchup at Wallace Wade Stadium in hot conditions pits two programs adjusting to roster and scheme shifts, with Duke holding home-field and experience edges in the early-season environment.